Cortical Spheroid Development Tracked with a Novel Imaging Platform(DNA-PRISM)Reveals Culture Complexity and Establishes Reproducible Phenotype Baseline for Compound Screens and Disease Modeling

摘要

Moving personalized medicine and drug candidates from the lab to the clinic will require addressing the current hurdles that impede high-throughput generation of experimental and clinical data.One such challenge with current imaging technology is its limited ability to provide large cross-sections of protein expression within the same sample for in-depth analysis of cellular processes.Traditional immunofluorescence enables acquisition in up to five channels before having to rely on specialized and expensive equipment that is not readily usable without extensive training or financial commitment.