Topical Cocfelfvery of an Antibiotic and a Protein from in Situ Forming Chitosan-Peg Hydrogel for Wound Healing Applications

摘要

Effective wound healing requires accelerated tissue regeneration and simultaneous inhibition of infection at the wound site.In situ forming hydrogels can be explored as candidates for wound management because of their viscoelastic characteristics,which translates into ease of application and ability to deliver multiple therapeutic agents,each with a discrete release kinetics1.In addition,the hydrogel-based wound care formulation must possess the ability to provide a moist environment and absorb dead cell debris and tissue exudates2.Chitosan has been extensively explored in variety of wound management devices,owing to its hemostatic and anti-infectious characteristics3.