Metal Ion Triggered Assembly of Peptide-Drug Conjugates

摘要

Metal ions play a crucial role in determining protein structures as well as regulating important biological processes.Through coordination,metal ions can induce changes in biomolecule conformation so as to alter their assembly outcomes.In this work,we present our rational design of iron chelator bearing peptide-drug conjugates(PDCs)that could exhibit morphological transition in the presence/absence of Fe(III)ions.A series of PDCs with nitrilotriacetic acid or 2,3-dihydroxybenzoic acid as iron chelator were synthesized.