Polymeric nanoparticle drug formulations can increase drug bioavailability and lower toxicity when compared to the free drug.However,nanoparticle formulations often require drying for long-term size stability.Traditional drying techniques,e.i.freeze-drying and spray-drying,require sonication and large amounts of cryoprotectants to avoid irreversible aggregation so the resulting dispersions can be hypertonic.
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