Effects of ~(99m)Tc on the Eedox Properties of L-Thyroxine

摘要

This paper presents the redox properties of hypothyroid drag L-thyroxine without and in the presence of sodium pertechnetate (~(99m)Tc) by an electrochemical method on glassy-carbon (GC) electrodes using a cyclic voltammetry technique. The cyclic voltammetry method was used to investigate the effects of various concentrations of L-thyroxine without and in the presence of ~(99m)Tc radiopharmaceuticals, the effect of the number of scan cycles, as well as the effect of ~(99m)Tc activity on the appearance of cyclic voltammograms. The results show that with the increase of the concentration of L-thyroxine, the increase of the peak current in the reduction area is notable. Obtained results show that the application of different concentrations of ~(99m)Tc on the drug exhibits the inhibitory properties of used radiopharmaceutical in the treatment of hypothyroidism.