In this research, we established a MPTP mouse model of PD, then ultrasound was used to stimulate the model to explore the effects of ultrasound on behavior and dopamine content in striatum. With the prolongation of ultrasonic stimulation time, the delay of observation time, the amount of DA in the striatum of the ultrasonic treatment group was increasing. Using ultrasound with a frequency of 1 MHz at an intensity of 0.3W/cm~2 over 15min for 1d, 5d or 10d respectively, in each group, there was a significant difference in the content of DA in the striatum compare to PD observation group at the same observation time(P<0.05). Especially, the DA content in the striatum of the mice treated with the ultrasound for 10 d was not statistically significant compared with the control group(P>0.05). Combined with the results of climbing test and open field test and general behavioral changes, the difference between ultrasound group and PD group reached a significant level (P<0.05). In summary, ultrasound can increase the DA content in the brain and improve the motor capacity of PD model. It suggests that ultrasound may be a safe and effective new method of PD treatment.
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