Detection of Prostate Specific Antigen Using Silicon Photonic Crystal Nanocavity Resonator

摘要

In this work, we investigated photonic crystal (PhC) based double nanocavity resonator biosensor. The sensor performance has confirmed by both sucrose and prostate specific antigen (PSA, a protein biomarker associated with prostate cancer). The device sensitivity and quality factor in sucrose solution are 1571 nm/RIU (Refractive Index Unit) and 2× 10~5 respectively. By using special antigen-antibody reaction, we successfully detected PSA concentration as low as 0.5 ng/mL.