Cross-linked Dexamethasone Sodium Phosphate Delivery Systems Based on Silver Doped Hydroxyapatite Scaffolds

摘要

One of the most used calcium phosphate implant materials in bone tissue regeneration is synthetic hydroxyapatite, which is similar to mineral phase of bone. By adding antibacterial effect to hydroxyapatite properties and creating controlled drug delivery systems based on this material, it is possible to obtain multifunctional material. Thus, in this study hydroxyapatite was doped with silver up to 1 wt% to provide antibacterial effect and from the obtained material dense and porous scaffolds were prepared. Prepared scaffolds were coated with chitosan and cross-linked with dexamethasone sodium phosphate (DEXA). Scaffolds were characterized and it is shown that linkage between chitosan coating and DEXA on the surface of hydroxyapatite and silver doped hydroxyapatite can ensure the controlled drug release up to 70 h.