Evaluation of Tanshinone IIA on Antitumor Effect and Mechanism of the Proliferation and Apotosis in Human Carcinoma Hep-2 Cells

摘要

Tanshinone IIA (Tan IIA) is an ingredient extracted from salvia miltiorrhiza, a traditional Chinese medicine, and has been used in the therapy of cardiovascular diseases. The study was designed to investigate the antitumor effect of Tanshinone IIA (Tan IIA) at different concentrations on the proliferation and apoptosis of human laryngeal carcinoma Hep-2 cells. MTT assay revealed that Tan IIA significantly inhibited the growth of Hep-2 cells in a dose dependent manner. Flow cytometry showed Hep-2 cells became apoptotic, and the early apoptosis rate was 5.8 %, 7.9 %, 10.2 % and 20.4 %. Tan IIA may inhibit the proliferation and induce the apoptosis of Hep-2 cells in a concentration dependent manner.