METHOD VALIDATION BY MEANS OF THE ACCURACY PROFILE: A REALISTIC APPROACH FOR ROUTINE CHEMICAL LABORATORIES

摘要

This paper describes the advantages and applications of a method validation approach based on the construction of an accuracy profile. This is currently employed by the laboratory of Trace Metals and Minerals of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES). The main analytical performance characteristics obtained for a selection of analytes by means of an in-house developed and validated multi-element ICP-MS method are presented. A brief comparison of the uncertainty calculated by using the GUM recommendations and by ANSES approach is also provided.