Etiology unknown; possible deficiency in growth hormone that develops after maturity; atrophy of pituitary gland in one case; adrenal sex hormone abnormality.Breed Predilection: Chow Chows, Keeshond, Pomeranian, Miniature Poodle. Age Predilection: 1-3 years old. Sex Predilection: intact male dogs.Clinical Features: Bilaterally symmetrical alopecia and hyperpigmentation, primarily neck, perineal, and genital regions, tail, posterior and medial thighs, ventral abdomen. Excess scaling and dull, dry hair coat. Fuzzy hair coat. Changes in hair coat color. Regrowth of hair in areas of full thickness trauma to the skin.Diagnosis: Skin biopsy—presence of eosinophilic tricholemmal keratinization ("flame follicles"). Growth hormone stimulation test. Low or normal baseline growth hormone levels with a poor response to stimulation (xylazine) can be normal for Pomeranians.Treatment: Growth Hormone treatment (bovine) 2.5 units (less than 14 kg), 5.0 units (greater than 14 kg) SQ every other day for 10 injections. Human Growth Hormone 0.15 IU/kg SQ twice weekly for six weeks.
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机译：病因未知;在成熟后发展的生长激素可能缺乏;垂体垂体腺体在一个案例中;肾上腺性激素异常。纤维倾向：味道，Keeshond，Pomeranian，微型贵宾犬。年龄偏见：1-3岁。性别偏好：完整的雄性狗。临床特征：双侧对称的脱发和高度沉着，主要是颈部，会阴和生殖器区，尾部，后和内侧大腿，腹部腹部。过度缩放和沉闷，干燥的毛发外套。模糊的毛发外套。毛发颜色的变化。在全厚度创伤区域的头发再生育到皮肤。诊断：皮肤活组织检查 - 嗜酸性滴毛颗粒角膜蛋白酶的存在（“火焰卵泡”）。生长激素刺激试验。低或正常的基线生长激素水平与刺激差（木嗪）的反应差（番茄嗪）对于Pomeranians而言可能是正常的。治疗：生长激素治疗（牛）2.5单位（小于14千克），每隔5.0个单位（大于14千克）Sq 10个注射液。人体生长激素每周两次0uu / kg Sq六周。
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