The nano structure derived from Anodic Aluminum Oxide (AAO) is controllable by the anodizing conditions such as voltage, anodizing time, and the acid solutions. Regularly arranged nano-pores were fabricated with high aspect ratio. We tried to use the nano structure as a template to build nanowire array on the quartz crystal to enlarge the surface area bond to analyte. Evaluating the shape of the nanowire, average of the height and the diameter of the nanowire were 1 μm and 50 nm, respectively. In this case, high aspect ratio more than 20 was achieved. We fabricated nanowires on the electrode of the QCM chip and tried to detect the antigen-antibody reaction.
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