The Role of the Organic Component in the Formation of Organo-Mineral Formations of Human Body

摘要

This work examined the protein composition of organic components for different organo-mineral aggregate in the bone tissue of healthy people (without bone disease) and patients with coxarthrosis (arthrosis of the coxofemoral joint), urinary, dental, and salivary calculi. The content of the water-soluble organic substances with a peptide bond in urinary stones depends on the mineral composition of the sample. When monohydrate calcium oxalate crystallizes in the solution in the presence of glutamic acid, the crystal growth is stabilized. When the concentration of amino acid grows, the inhibitory effect grows. Other amino acids (lysine, glycine, aspartic acid) have an inhibitory effect on hydroxyapatite crystal growth in the range of the tested concentrations. By an increase in the electrostatic interaction with non-stoichiometric hydroxyapatite, the tested amino acids can be ranked in order as: lysine > glycine > glutamic acid > aspartic acid. In the course of bone arthrosis, the molecular weight of the organic content was observed to be less than that of collagen. Close packing of the deformed collagen fibers was one of the causes of the increased hardness of arthritic bones. The amino acid composition in the bone tissue of men and women in the age range of 30-79 to 60 years does not depend on the age and gender identity of the samples. After 60 years, the amino acid content varies by age and gender.