Synthesis of 5-(4-bromophenyl) - 4, 6- dichloropyrimidine

摘要

The pyrimidine compounds are a class of nitrogen-containing heterocyclic compounds. 5-(4-bromophenyl)-4, 6-dichloropyrimidine is an important intermediate in the synthesis of pyrimidines, dimethyl2-(4-bromophenyl) malonate and 5-(4-bromophenyl) pyrimidine-4,6-diol are important intermediates in compound 1. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available methyl 2-(4-bromophenyl) acetate through three steps. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 52.8% (calculated from methyl 2-(4-bromophenyl) acetate).