Improvements in biodetection: Role of the recognition element

摘要

For small molecules, immobilization has a significant effect on structure, function: - Location of attachment, tethering moiety, surface itself; - Inter-molecular effects. More is not always better. Seemingly analogous chemistries may result in quite different results: - Presentation is critical, but can't be easily predicted. Structural studies may be helpful, but should be performed under variety of conditions: - Structure-function relationships cannot be predicted...