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IDENTIFYING THE DRIVERS OF BONE CANCER PAIN IN CANINE OSTEOSARCOMA

机译:鉴定犬骨肉瘤中骨癌疼痛的驱动因素

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The true prevalence of cancer pain in dogs and cats is unknown; however given the conserved biology of cancer between companion animals and people1"3, it is plausible that the incidence of cancer pain is comparable for these two species. Pain is a common ailment in human cancer patients. Based upon epidemiologic studies, the incidence of cancer pain at initial diagnosis approaches 30%, and upon disease progression up to 65-85%> of human cancer patients will experience pain at some point.4"8 Correlating with its high reported incidence, pain is the most common physical symptom in people diagnosed with terminal cancer.Cancer pain negatively affects quality of life as well as many important physiological functions, and its alleviation in patients should be an utmost clinical and humane priority. No cures exist for many patients suffering from advanced cancer; however effective analgesic strategies can diminish the discomfort and suffering associated with terminal disease progression. Estimates indicate that more than 70% of human cancer patients suffering from pain can be relieved with opioid-based regimens4' n"13, and it is justifiable to believe that equally effective cancer pain management is achievable for companion animals too. However, for cancer pain to be adequately managed, it must be recognized early and frequently reassessed by veterinary caregivers and pet owners. Despite the treatability of cancer pain, many barriers obstruct its optimal management in animals, including poor recognition associated with many cancers, difficulty in response assessment, limited knowledge regarding the usage of analgesics,and suboptimal communication between veterinary caregivers and pet owners.
机译:狗和猫的癌症疼痛的真正患病率未知;但是,鉴于伴侣动物和人民1“3之间的癌症生物学的生物学,它是合理的,即癌症疼痛的发生率与这两个物种相当。疼痛是人类癌症患者的常见疾病。基于流行病学研究,癌症发生率初步诊断的疼痛方法30%,疾病进展,高达65-85%的人类癌症患者会在某些时候体验疼痛.4“8与其高报道的发病率相关,疼痛是人们诊断的人民最常见的身体症状患者癌症。癌症疼痛对生活质量产生负面影响以及许多重要的生理功能,并且其对患者的缓解应该是最大的临床和人道优先权。许多患有先进癌症的患者没有治愈;然而,有效的镇痛策略可以减少与末端疾病进展相关的不适和痛苦。估计表明,超过70%的人癌症患者患有疼痛的患者可以通过基于阿片类药物的方案4'n“13来缓解,并且可以相信同样有效的癌症疼痛管理也是可实现的伴侣动物。然而,癌症要充分管理的痛苦,必须尽早认可,经常被兽医护理人员和宠物业主重新评估。尽管癌症疼痛的可治工,但许多障碍阻碍了动物的最佳管理,包括与许多癌症相关的差,难度评估难度,关于镇痛药的使用的有限知识,兽医照顾者与宠物业主之间的次优沟通。

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