Histopathological and immunohistochemical characterization of pigs experimentally infected with porcine deltacoronavirus

摘要

Porcine deltacoronavirus (PDCoV) is an emerging virus which has recently been detected in US and Canadian swine herds associated with outbreaks of diarrhea in the absence of other etiologic agents.1 Most reports associating PDCoV with enteric diseaseis from field cases, and thus controlled experimental evidence of PDCoV as an etiologic agent is lacking. The objective of this study was to develop a challenge model for controlled experimental PDCoV infection in neonatal piglets and to characterize the clinical course of disease, virus distribution in tissues, and histopathology subsequent to PDCoV infection.