Synthesis of Micro-nanostructured TiO_2 Sphere with Homogeneous Precipitation assisted by Microwave Irradiation and its Drug Loading Capacity

摘要

Nanoparticulate titanium dioxide were synthesized via homogeneous precipitation assisted by microwave irradiation. The powder was characterized by X-ray diffraction(XRD), Scanning Electron Microscopy(SEM), Differential scanning calorimetry and thermogravimetric analysis(TG-DSC), Roman spectra and Transmission electron microscopy(TEM). The results showed that obtained TiO_2 were pure-phase anatase with BET Surface Area of 53.9445m~2/g and the average pore diameter of 9.3439nmand 800°C is the crystal phase transformation temperature, exhibited high drug loading capacity towards sorafenib of 5.65% while the TiO_2/sorafenib ratio at 15:5 for 6h under stirring condition. Micro-nanostructured TiO_2, as a drug delivery system, has great potential in the treatment of cancer diseases.