The Effect of Glycosaminoglycan from Urechis unicinctus on the Protein C system and Relevant Factors Expression of HUVECs

摘要

The influence of glycosaminoglycan from Urechis unicinctus on the protein C system and relevant factors expression of human umbilical vein endothelial cells (HUVECs) were studied with enzyme linked immunosorbent and reverse transcript-polymerase chain reaction (RT-PCR). Results indicated that: glycosaminoglycan could significantly decrease content of activated protein C, activated protein S in blood of rats (P<0.05, P<0.01), significantly elevated content of activated protein C inhibitor (P<0.05, P<0.01), slightly increase the thrombomodulin level. Glycosaminoglycan could significantly reduce the expression of tissue factor gene, promote the expression of tissue factor pathway inhibitor and thrombomodulin gene (P<0.01).