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A Computational Study on Traveling Waves in the Gerbil Cochlea Generated by Electrical Impulse

机译:电脉冲生成耳蜗中波浪的计算研究

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Through model simulations, we investigated the cochlear traveling waves formed by outer hair cell (OHC) motility. Two sets of governing equations, one representing the solid domain of the organ of Corti complex (OCC) and the other representing the fluid domain, were solved simultaneously in the time domain. The OHCs incorporated electro-mechanical motility driven by prestin molecules. The combined fluid-solid interaction model was verified by simulating passive traveling waves along the cochlear coil. When stimulated with an electrical impulse, the OCC formed traveling waves propagating toward the apex. Without the Y-shaped structures in the OCC formed by the OHCs and the Deiter's cell processes, the active OHCs form dispersive waves rather than traveling waves upon electrical stimulation.
机译:通过模型模拟,我们研究了由外发细胞(OHC)运动形成的耳蜗行驶波。在时域同时解决了两组表示皮质复合器器官(OCC)和另一代表流体域的另一个代表流体域的实体结构方程。 OHCS掺入了普雷斯汀分子驱动的电力机械运动。通过沿着耳蜗线圈模拟被动行进波来验证组合的流体固体相互作用模型。当用电脉冲刺激时,OCC形成朝向顶点传播的行驶波。在OCCS和DEITER的细胞工艺形成OCC中没有Y形结构,活性OHCS形成分散波而不是在电刺激时行进波。

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