A novel chitosan microbubble as ultrasound-triggered drug carrier for antitumor in vitro

摘要

Uniform Microbubbles(MBs) were routinely used as ultrasound contrast agents, but the MBs served for drug carrier showed well-marked advantage. In this study, we prepared a novel docetaxel-loaded microbubbles by carboxymethyl chitosan with W/O/W emulsion technique. Then, the surface morphology was characterized by scanning electron microscope(SEM). Ultrasound-triggered drug release experiments were performed with adjustable intensity and time. In the antitumor experiment in vitro, Ultrasound-assisted drug release from MBs exhibited good treatment of tumor. The results proved the combination of ultrasound and drug-loaded carboxymethyl chitosan microbubbles could be used as a potential strategy for anti-tumor therapy.