SNP Affects the Mobility of Breast Cancer Cells and the Expression of Metastasis-Related Genes

摘要

Protein S-nitrosylation is a type of posttranslational modification that changes protein stability, intracellular localization, and biological activity. In mammalian cells, NO is synthesized by NOS which is highly expressed in many solid tumors, including breast cancer. NOS is involved in the progress of carci-nogenesis by generating NO to modify various tumor-related proteins to enhance or suppress their function. However, the effect of NO on tumor metastasis is less studied. Herein, breast cancer cells MCF-7 and MDA-MB-231 were treated with NO donor SNP, which resulted in altered cell mobility. Meanwhile the expression of several metastasis-related genes was regulated. These results suggest a novel mechanism by which NO promotes the metastasis of breast cancer.