A Transdermal Miniature Syringe Design Based on Port Ontology for Drug Delivery

摘要

In clinic practice, a strong appeal for painless transdermal injection is pursued, especially for patient drug delivery that cannot be administered orally. A new disposable painless syringe with MEMS technology is presented. The mode of micro needle array and a flexible PDMS container of hemisphere shape are given, and the behavior of the drug liquid flow through the needles is described based on port ontology to model miniature syringe and explains the phenomena of clog formation. The analysis and formulas have theoretically been derived, and the performances and the clog phenomena have been simulated. Therefore, micro needles inserted into the human skin can realize painless injection based on port ontology modeling.