Single site maximum coronary stenosis on computed tomography angiography predicts total coronary plaque burden

摘要

Objectives: To determine if single site maximum stenosis of coronary artery disease (CADmax) on computed tomographic angiography (CTA) predicts coronary plaque burden measured by calcium score (CAS) or CTA plaque burden score (PBS). Background: The COURAGE trial showed coronary plaque burden and CADmax predict adverse coronary events. However, it has not been shown whether maximum single site coronary stenosis predicts the plaque burden for the entire coronary vasculature on CTA. Methods: CTA studies of 147 subjects (mean age 58.2±10.6) were reviewed for CAS and PBS (by summing CAD extent and severity from standard coronary CTA segments). CADmax for the entire coronary tree was categorized as 0%, 1-49%, 50-74% and 75-100% stenosis. Results: CADmax was >0% in 74 (50%) patients. PBS and CAS were found to be higher in males and increased with age. Multiple linear regressions following chi-squared analysis and ANOVA demonstrated an association between CADmax and CAS and PBS. Conclusions: Single site maximum coronary stenosis on CTA generally predicted the total coronary burden independent of age and other risk factors and regardless of how coronary plaque burden was determined.