Lipoprotein fractions and sub-fractions and heart proteases during acute lipemia in a murine model of atherosclerosis

摘要

Serum lipoprotein (LP) fractions and ^fractions of cholesterol (C) and triglycerides (TG) are useful in the diagnosis of early-onset atherosclerosis. The effect of acute lipemia induced by different doses of poloxamer 407 (P-407) in mice was studied. A significant dose-dependent increase in serum total LP-C and LP-TG concentrations, as well as an increase of atherogenic fractions of VLDL-LP and LDL-LP was shown. A drastic increase (55-fold) in VLDL-C (VLDL_(3-5)-C subfraction) was shown when P-407 was administered at a dose of 1000 mg/kg. Additionally, there was a significant increase in the LDL-C (LDL_(1-3)-C subfraction) when P-407 was dosed at 500 mg/kg. Lastly, the HDL-C fraction (HDL_2-C subfraction) was moderately increased with P-407 treatment.