Commercializing Unique Nanoparticle-Imaging-Delivery Platform for Enhanced Cancer Therapy

摘要

We have developed a versatile NID~(TM) (Nanoparticle-Imaging-Delivdry) platform that enables utilizing precisely engineered nanoparticle properties for specfic biomedical applications. The NID~(TM) platform generates nanoparticles with optimal size, shape, surface, magnetic and optical properties. Our nanoparticles demonstrate enhanced properties for cancer diagnosis and treatment applications. Examples are provided here for cell separation utilizing magnetic and fluorescent magnetic nanoparticles that could be applied for fast identification of circulating tumor cells, and for cancer drug delivery utilizing multifunctional nanoparticles with extremely enhanced permeability and retention effect, >30 day cancer region retention after single dose intraveneous injection, controllable pharmacokinetics, all FDA approvable component materials, and superior magnetic, fluorescent and cancer targeting proerties.