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首页> 中文期刊> 《纳米研究：英文版》 >Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

         
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摘要

Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications.Herein,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),respectively.Utilizing the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection.While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal clearance.Our work presents the great promise of 2D NMOFs for nanomedicine applications.

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  • 来源
    《纳米研究：英文版》 |2019年第6期|P.1307-1312|共6页
  • 作者

    Wenjun Zhu1; Yu Yang2; Qiutong Jin1; Yu Chao1; Longlong Tian1; Jingjing Liu1; Ziliang Dong1; Zhuang Liu1;

  • 作者单位

    [1]Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University,Suzhou 215123,China;

    [2]State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Avenida da Universidad,Taipa,Macau 31608,China;

    [1]Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University,Suzhou 215123,China;

    [1]Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University,Suzhou 215123,China;

    [1]Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University,Suzhou 215123,China;

    [1]Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University,Suzhou 215123,China;

    [1]Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University,Suzhou 215123,China;

    [1]Institute of Functional Nano & Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University,Suzhou 215123,China;

  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类 物理学;
  • 关键词

    nanoscale metal-organic-framework; two-dimensional nanosheets; drug delivery; photodynamic therapy; combination therapy;

    机译：纳米级金属有机框架;二维纳米片;药物输送;光动力疗法;联合疗法;
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