Chapter 16 Spontaneous and Induced Mutagenesis: The Necessity and Possibilities of Its Prevention with the Grape Polyphenolic Concentrate Enoant

摘要

The use of antioxidants from natural products for gene reparation may be better than those of a synthetic origin due to their low toxicity and apparent absence of adverse side effects. Grape polyphenols contain antioxidants having antimutagenic qualities. Particularly, the food concentrate Enoant, rich in grape polyphenols and extracted from Cabernet Sauvignon grapes, is a valuable source of natural antioxidants. In the current study, we investigated the possibility of using Enoant to modify the cytogenetic changes caused by spontaneous (due to aging) or induced (by thyroid hormone Т4 and by ionizing radiation) mutagenesis. The cytogenetic effects of Enoant were characterized depending on dosage, application time, age and sex.