Oral contraceptives as a risk factor for developing breast cancer in women in the state of Alagoas: Case control study

摘要

Objective: To evaluate the use of oral contraceptives (OC) as a risk factor for breast cancer. Methods:Data collection was conducted through interviews in hospitals as an instrument having a protocol previouslydeveloped and tested. The sample size was 752 patients divided into 299 cases to 453 controls obtained in theperiod 2001 to 2010. Data were analyzed in SPSS 6.0 using the chi-square test, Mann-Whitney/Wilcoxon Two-Sample test and calculating the ratio oddis. Results: Among the respondents, it was observed that 391 (52%)women used OC, 121 in the case group (40%) and 270 women in the control group (60%). There wasn’tassociation between oral contraceptive use and breast cancer, OR = 0.46 (OR <1), 95% CI (0.34 to 0.62) andwhen analyzing the sample with respect to time of use, we found no statistical significance, but when we use acut-off point of 60 months, we achieved statistical significance but the use of OC did not behave as a risk factor(OR=0.39 and IC 95%). Regarding the use of the OC before the first pregnancy also did not detect anassociation, we had an OR of 0.46 IC 95%. Conclusion: There was no association between the use of OC withthe development of breast cancer in general, with time of exposure and onset of use before first pregnancy,although these variables have shown statistical significance.