Mathematical Modelling of the Function of Ubiquitylation in TNFR1-Mediated NF-kappaB Signalling

摘要

The tumor necrosis factor receptor 1 (TNFR1) pathway plays a crucial role in immune signalling and development by controlling cell growth and death [7]. The binding of tumor necrosis factor-alpha (TNFalpha) to TNFR1 can either trigger two different forms of cell death - apoptosis and necroptosis - or promote cell survival due to the activation of the transcription factor nuclear factor-kappaB (NF-kappaB) [5]. A dysregulation of this pathway can result in chronic diseases and cancer-related inflammation and features a strictly controlled regulatory network [6]. Therefore, the logic of the pathway regulation is of interest for cancer research to recognise the mechanisms that determine the outcome of death receptor stimulation.