In Vitro Activation of Steroid Receptors in Corneal Epithelial Cells Using a Novel Anti-inflammatory Liposomal Formulation

摘要

Unpreserved liposome-based formulations were loaded with the anti-inflammatory agent medroxyprogesterone (mdx). We aimed at determining the in vitro activation of steroid receptors in corneal epithelial cells after exposure to mdx-loaded liposomes (mdx-lipo). For that purpose, the Human Corneal Epithelial (HCE) cell line was exposed to formulations for 1 h. Exposure of HCE cells to mdx-lipo leads to an activation of glucocorticoid and progesterone receptors and a reduction in proliferation rate. Therefore, we consider this novel liposome-based formulation potentially useful as anti-inflammatory drug delivery system.