Prediction of Bone Implant Interface Based on a Molecular Level Interaction

摘要

Uncontrolled interactions between synthetic materials and human tissues are a major concern for implants and tissue engineering. It is well recognized that osteoblasts (bone cells) preferentially adhere to specific amino acid sequences such as arginine—glycine—aspartic acid (RGD) and heparin-sulphate ligand binding regions in adsorbed proteins. Accordingly, how specific amino acid sequences are exposed in adsorbed proteins to associate with binding to integrin receptors in cell membranes is critical to whether cell adhesion will occur on an implant surface. The abundance of positive binding sites to electron deficient sites of the protein molecules presents a strong case for adhesion of these cell adhesion li-gands on to a biomaterial surface. This paper reviews the study based on a molecular orbital interactive method for prediction of the biocompatibility of implants based on a pro- tein-biomaterial surface interaction.