Fabrication of In Situ Cross-Linking Polyvinyl Phosphonic Acid - Chitosan Hydrogel for Wound Applications

摘要

The use of natural polymer as scaffold material in hydrogels has been applied for skin regeneration due to their high biocompatibility, low toxicity, and biodegradability. Hydrogel was synthesized by in situ crosslinking of polyvinyl phosphoric acid (PVPA) and chitosan (Cs) in this study. Fourier transform infrared spectrum (FT-IR) analysis and scanning electron microscope (SEM) were used to confirm characteristics of hydrogel. The results showed that the crosslinking was formed successfully, and the inner morphology of hydrogels was appropriate for wound application.