Synthesis of p,y-bridging oxygen-modified ribavirin 5'-triphosphates

机译：P，Y桥氧改性利巴韦林5'-三磷酸酯的合成

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A novel P(V)-N activation strategy for the synthesis of (β,γ-bridging oxygen-modified ribavirin 5'-triphosphates (β,γ-CX_2-NTPs, X = H, F, and Cl) from protected ribavirin 5'-phosphoropiperidates has been developed. The experimental results indicated that the employment of DCI activator could notably increase the product yield.

机译：一种新的p（v）-n合成（β，γ-桥接氧气改性利巴林5'-三磷酸（β，γ-cx_2-ntps，x = H，F和Cl）的活化策略，来自受保护的利巴韦林5已经开发了'-磷磷哌啶。实验结果表明，DCI活化剂的就业可以显着提高产物产量。

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《International Conference on Intelligent Materials and Mechanical Engineering》|2014年||共4页
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Qiang Wang; Shan-Shan Gong; Qi Sun;
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中图分类 TB3-532;
关键词
ribavirin; nucleoside triphosphate; 4; 5-dicyanoimidazole; antiviral; phosphoropiperidate;

机译：利巴韦林;三磷酸核苷;4;5-二氰酰亚胺唑;抗病毒;磷脂;

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1. Efficient synthesis of nucleoside 5'-triphosphates and their β,γ-bridging oxygen-modified analogs from nucleoside 5'-phosphates [J] . Qi Sun, Shanshan Gong, Jian Sun Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2014,第13期

机译：从核苷5'-磷酸高效合成核苷5'-三磷酸及其β，γ-桥氧修饰的类似物
2. Efficient synthesis of nucleoside 5'-triphosphates and their β,γ-bridging oxygen-modified analogs from nucleoside 5'-phosphates [J] . Qi Sun, Shanshan Gong, Jian Sun Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2014,第13期

机译：从核苷5'-磷酸高效合成核苷5'-三磷酸及其β，γ-桥氧修饰的类似物
3. Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. [J] . Hitomi Y, Cirulli ET, Fellay J, Gastroenterology . 2011,第4期

机译：肌苷三磷酸通过腺苷琥珀酸合酶功能防止病毒唑诱导的三磷酸腺苷丢失。
4. Synthesis of p,y-bridging oxygen-modified ribavirin 5'-triphosphates [C] . Qiang Wang, Shan-Shan Gong, Qi Sun International Conference on Intelligent Materials and Mechanical Engineering . 2014

机译：P，Y桥氧改性利巴韦林5'-三磷酸酯的合成
5. Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: Synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted triphosphates. [D] . Chamberlain, Brian Thomas. 2012

机译：用于研究DNA聚合酶结构和机理的脱氧核苷酸类似物探针和模型化合物：烷基，叠氮基和卤代亚甲基双膦酸酯取代的三磷酸酯的合成和评估。
6. Activity of Ribavirin against Hantaan Virus Correlates with Production of Ribavirin-5′-Triphosphate Not with Inhibition of IMP Dehydrogenase [O] . Yanjie Sun, Dong-Hoon Chung, Yong-Kyu Chu, 2007

机译：利巴韦林抗汉坦病毒的活性与利巴韦林-5-三磷酸的产生有关而不与IMP脱氢酶的抑制有关
7. Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus [O] . Kristina Nyström, Paulina H. Wanrooij, Jesper Waldenström, 2018

机译：在丙基磷酸三磷酸三磷酸盐磷酸盐磷酸盐磷酸盐磷酸盐酸二磷酸酯和减少酶活性脱乙酰磷酸盐酶诱变中的丙肝炎病毒

Synthesis of p,y-bridging oxygen-modified ribavirin 5'-triphosphates

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