Differenze di genere nella risposta al trattamento dei Disturbi Affettivi

摘要

Gender differences has been emphasized in treatment both of Unipolar Depression and of Bipolar Disorder. A better response to SSRI and, in a minor extent, to SNRI and IMAO seems to occur in women; for same dosages, women's TC plasma levels appear higher than men's. Women show a better response to mood stabilizers and a major frequency of Rapid Cycling induction. Various mechanism are supposed to underlie these differences, including estrogen effects on monoaminergic transmission and pharmacokinetic differences between the sexes.