Drug Safety nella Farmacoterapia Antipsicotica della gravidanza e dell'allattamento

摘要

Drug Safety in pregnancy and lactation Antipsychotic Pharmacotherapy.The use of antipsychotic drugs, regardless of dose and exposure time, is associated with potential structural teratogenic effects on the fetus together with perineonatal and postnatal complications and neurobehavioral sequelae.There are few specific datas on antipsychotics' pharmacokinetics and pharmacodynamics in pregnancy therefore the guidelines for therapy are based on observational studies and basic principles.All antipsychotics can pass through placenta and in milk during pregnancy and lactation. Their administration in pregnancy can result in maternal metabolic complications (gestational diabetes, gestational hypertension and obesity, associated with neural tube defects) and fetal macrosomia in the newborn. Neonatal extrapyramidal adverse effects are less frequent compared to FGA.