Fabrication of Nano-Fibrous Poly(L-Lactic Acid) Scaffold Enhanced By Silane Modified Chitosan Fibers

摘要

In this study, A PLLA/silane modified chitosan fiber composite scaffold was sucessfully prepared using thermal induced phase separation method. The PLLA was chemically coupled with chitosan fiber surface using γ-methacryloxypropyl-trimethoxysilane. The composite scaffold had a nano-fibrous PLLA matrix (fiber size 200-750 nm), an interconnective pores ((1-6 μm), high porosity (>90%). Introduced surface modified chitosan fibers into PLLA matrix, it significantly enhanced the nano-fibrous scaffold. The new nano composite scaffold is potentially a very promising scaffold for tissue engineering.