Limited availability of licensed veterinary medicines for controlling diseases is one of the major problems in the Mediterranean aquaculture industry. Sanitary risks are increasing and the economic impact of diseases challenges the sustainability of the companies. For this reason, health management programmes should be emphasized in order to minimize the use of antimicrobials in fish farms. Administration of veterinary medicines through medicated feeding stuffs is the preferred method for treating fish in modern aquaculture. In this paper, the process of oral delivery of veterinary medicines is discussed from a practical point of view. The four parts of a prudent and responsible oral treatment are (1) early and accurate diagnosis of the disease; (2)proper selection of premix and dose; (3) good manufacturing of the medicated feedingstuffs; and (4) correct administration of the medicated feedingstuffs. The final success of the treatment will depend on the success of each separate part.
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