Cognitive behavior therapy ameliorates non-motor symptoms in Parkinson's disease

摘要

Non-motor symptoms (NMS) occur commonly in PD patients. The NMS is associated with the deterioration of life quality in Parkinson's disease (PD), even exceeding the effects of the motor disorder. To determine the effects of cognitive behavior therapy (CBT) on NMS in PD, fifty-five PD individuals with CBT intervention were matched for forty-eight control PD participants. NMS of all PD patients including depressive symptoms, sleep quality, cognitive function and physical and mental health-related quality of life were respectively assessed. Results indicate that CBT ameliorates NMS of PD patients, and that is significantly related with the decreases of serum inflammatory cytokines levels.