Design and Simulation of a High Precision Drug Delivery System

摘要

This work describes the design and simulation using Computational Fluid Dynamics (CFD) of a High Precision Drug Delivery System which is part of a bionic pancreas. The system interacts in a dynamic and intelligent way with other subsystems of the device, which includes a non-invasive monitor of glucose and the control algorithm for the entire system. P-MEM Microfabrication technology brings the opportunity to construct these devices in the scale of micrometers, in order to have a device with high portability, low power consumption, reliability and low cost. The system has the potential to deliver highly controlled doses of insulin and glucagon in order to achieve a high level of personalization of the therapy. This paper will discuss the design parameters of the device, velocity, pressure and dimensions. Velocity determines the possibility to create monodisperse microdroplets, and pressure the validity of the microfabrication process.