Acoustical Studies of Cationic Surfactant-cetyltrimethyl Ammonium Bromide in the presence of Furosemide at different Temperatures

摘要

In the present work, sound velocity parameters have been calculated from density and sound velocity measurements of cardiovascular drug Furosemide in the presence of cationic surfactant cetyltrimethyl-ammonium bromide (CTAB) at different temperatures. These parameters include Specific acoustic impedance (Z), Intermolecular free length (L), Sound velocity number [U] and Relative association (R.A.). The variation of these parameters at different concentrations of drug with CTAB has been analysed in order to understand the synergistic behavior of drug-surfactant complex. The studies reveal the presence of drug-drug, drug-surfactant and drug-solvent interactions which can be related to electrostatic as well as hydrophobic interactions.