Thymus pathology observed in the MGTX trial

摘要

The MGTX trial is the first prospective, randomized clinical trial that aims to evaluate the impact of extended transsternal thymectomy onmyasthenic symptoms, prednisone requirements, and quality of life in patientswith nonthymomatous, anti-acetylcholine receptor autoantibody-positivemyasthenia gravis (MG).Here, we give an overview of the rationale of thymectomy and the standardized macroscopic and histopathological work-up of thymectomy specimens as fixed in MGTX standard operating procedures, including the grading of thymic lymphofollicular hyperplasia and the morphometric strategy to assess thymic involution.