Optimization of the Fermentation Process for Streptomyces lydicus A02 Producing Natamycin

摘要

@@ Streptomyces lydicus A02 was isolated from forest soil in a suburb of Beijing. The strain presented a stable and strong antagonistic activity against many plant pathogenic fungi, such as Botrytis cinerea，Alternaria solani, Fusarium graminearum，Rhizoctonia cerealis and others. Studies showed that the main active component of strain A02 is natamycin, a natural fungicides. We have developed a microcapsule formulation of natamycin produced by strain A02. Using the microencapsulated natamycin, high control efficiencies towards vegetable grey molds (up to appr. 90%) were obtained by potted plant trials performed in the greenhouse. In order to increasing productivity and reducing production costs of the natural fungicides, we optimized the fed batch fermentation process of Streptomyces lydicus A02 producing natamycin.