Polyion complex micelles incorporating poly (aryl benzyl ether) dendritic phthalocyanine: effective photosensitizers for enhanced photodynamic therapy

摘要

A novel series of zinc (II) phthalocyanines bearing four poly (aryl benzyl ether) dendritic substituents with carboxylic acid functionalities (G_n-DPcZn (G_n=n-generation dendrimer, n=1-2)) loaded polymeric micelles (G_n-DPcZn/m) were formed. The time-dependent intracellular uptake of Gn-DPcZn in RPE cells increased as they were incorporated into micelles, but inversely correlated with the generation. The photocytoxity of G_n-DPcZn was improved by incorporation into polymeric micelles and increased with the generation.