24.Protective Effect of Endurance Exercise Training on Brain Antioxidant System in Old Age Rats Treated with Alcohol: A Comparison with Young Age Rats

摘要

Elder subjects are more prone to alcohol-induced oxidative damages, particularly to brain tissue. The present study was carried out to examine the impact of exercise training on alcohol-induced oxidative damage and diminished antioxidant status in the brain of aged rats comparing with young ones. The age-matched Wistar albino rats (3 months young, n=24; 18 months old, n=24) were evenly divided into four groups and treated as, normal control (NC), exercise trained (Ex), alcohol treated (At) and exercise plus alcohol treated (Ex+At). With alcohol treatment, brain antioxidant enzyme activities including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and the content of glutathione (GSH) were significantly (p <.001) decreased. These changes were found to be greater in the aged rats than those of the young rats. However, in our study, reduced antioxidant status with alcohol treatment was significantly reversed by exercise training. This was shown as improved activities of antioxidant enzymes along with GSH levels by exercise combination treatment in the brain of o!d rats. These results suggest that exercise training is potential to reverse the deteriorated antioxidant enzyme status in the brain of elderly alcohol treated rats.