Injury on blood systems caused by Silicon dioxide nanoparticles

摘要

Nano-sized silicon dioxide (SiO_2) is widely utilized in artificial bone, artificial tooth, interventional catheters and drug delivery system, so it is imperative to study SiO_2 NPs on the role of the body damage. Consulted with standard reference of GB/T16886, 20 and 80 nm SiO_2 NPs were selected to prepare suspension (1mg/ml) for subacute systemic toxicity; 2000mg/ml suspension for MTT; and extracts (0.lg/ml) for hemolytic test. The results show that the hemolysis rate are all more than 5%, after its continuous injection of 2W nanoparticles into SD rats and New Zealand Rabbits, the alterations on the hemoglobin, hematocrit, mean corpuscular volume and other indicators have gained in blood routine test, and there was a marked inhibition on the L929 cells of SiO_2 NPs. Therefore, these two kinds of particle size of SiO_2 NPs have certain extent of injury effect on the blood system, and the contact time of NPs in the blood compatibility evaluation has play a more important role than the others.