Graphene oxide-reinforced hollow fiber solid-phase microextraction coupled with HPLC for the determination of parabens in beer

摘要

An effective and sensitive method to determinate four parabens was developed by using graphene oxide (GO)-reinforced hollow fiber (HF) solid-phase microextraction combined with HPLC-PDA. Scanning electron microscope characterizations indicated that graphene oxide was successfully synthesized and modified in the pores of HF by ultrasonication. The conditions including extraction time, desorption time were optimized. The liner ranges of parabens were 0.01-5.00 μg/mL via the proposed management with a limitation of detection of 0.005 μg/mL. The extraction procedure based on GO-HF was successfully used for the determination of parabens in beer.