@@ Reversible acetylation and deacetylation of ε-amino group of lysine residues on histone tails by histone acetyl transferase (HAT) and histone deacetylase (HDACs) enzymes play a crucial role in the epigenetic regulation of gene expression by changing the chromatin architecture and transcriptional activity[1]. HDACs can cause high histone deacetylation, lead to cancer developments including the control of cell cycle arrest, differentiation and apoptosis. HDAC inhibitors (HDACIs) have the potential of prevention proliferation of cancer, and emerged as an attractive target as anticancer drugs[2]. Cyclic peptides are one of the most important class of HDACIs.
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