Enantioselective Cytotoxicity and Molecular Mechanisms of Modern Chiral Pesticides

摘要

The agrochemical industry and government regulators are beginning to take enantioselectivity into account since up to 40% of pesticides are chiral. Cytotoxicity has been developed as an effective method for assessing the eco-safety and health risks of chiral pesticides in diverse in vitro models. The application of in vitro models may promote understanding of the molecular mechanisms of the enantioselective toxicity of chiral pesticides. In this review, we discuss the enantioselective cytotoxicity of chiral insecticides and herbicides and possible molecular mechanisms. The future role of in vitro techniques in the risk assessment of chiral chemicals will expand in light of recent developments in technologies such as genomics and system biology.