Antitumor activity of the polyether ionophorous antibiotic Monensin and its metal(II) complexes

摘要

The cytotoxicity of the polyether ionophorous antibiotic Monensin and its complexes [M(Mon)_2(H_2O)_2] (M = Mg, Ca, Co, Mn) was evaluated against permanent human tumor/non-tumor cell lines and virus-transformed animal tumor cell lines using various methods. The study had shown that generally Monensin complexes possess enhanced cytotoxic activity (lower cytotoxic concentration 50, CC_(50)) than the initial compound. The cytotoxicity values of some metal(II) complexes are comparable ([Co(Mon)_2(H_2O)_2], [Mn(Mon)_2(H_2O)_2]) or better ([Mg(Mon)_2(H_2O)_2], [Co(Mon)_2(H_2O)_2]) with respect to the properties of cisplatin and 5-fluorouracil, respectively.